Technology Platforms

Chemical Peptide Synthesis by p53 Lab

The platform technology from p53 lab allows for the chemical synthesis of chemically modified or constrained peptides less than 20 amino acids in length.

These macrocyclic or stapled peptides are more resistant to proteolysis, opening a new avenue of therapeutic modality. These macrocyclic or stapled peptides have shown improved binding and stability in in-vitro studies

Scope of Service

Custom peptide synthesis of up to 20 residues
Choice of C-terminal residue: acid, amide, alcohol
Published cyclic peptides targeting the p53/MDM2 interaction: PM2, VIP65, VIP116, VIP82, ATSP7041,
And a semi-custom p53/MDM2-targeting cyclic peptide (last 3 amino acids of your choice)

Crystal structure of our Stapled Peptide (scaffold) with Target (surface rendition) in an electron density 2fo-fc map, shown using a mesh contoured at 1.5σ

Our talented Chemical Synthesis team is able to incorporate unnatural amino acids, constrained peptides as well as modifications to the N- and C- terminus of these peptides. These modifications open up new opportunities in understanding the Structure-Activity Relationship of these peptides and their targets

Our key differentiation is our in-house technology that enables the synthesis of Peptide-Alcohols easily and cost-effectively_[1].

1: Ferrer Gago et al., 2019. DOI: 10.1002/chem.201903965