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Chemical Peptide Synthesis by p53 Lab |
The platform technology from p53 lab allows for the chemical synthesis of chemically modified or constrained peptides less than 20 amino acids in length. These macrocyclic or stapled peptides are more resistant to proteolysis, opening a new avenue of therapeutic modality. These macrocyclic or stapled peptides have shown improved binding and stability in in-vitro studies |
Scope of Service |
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Crystal structure of our Stapled Peptide (scaffold) with Target (surface rendition) in an electron density 2fo-fc map, shown using a mesh contoured at 1.5σ |
Our talented Chemical Synthesis team is able to incorporate unnatural amino acids, constrained peptides as well as modifications to the N- and C- terminus of these peptides. These modifications open up new opportunities in understanding the Structure-Activity Relationship of these peptides and their targets Our key differentiation is our in-house technology that enables the synthesis of Peptide-Alcohols easily and cost-effectively[1]. 1: Ferrer Gago et al., 2019. DOI: 10.1002/chem.201903965 |