VAHTS DNA Clean Beads are designed based on solid phase reverse immobilization (SPRI) and suitable for DNA purification and size selection during library preparation for high-throughput sequencing. The beads are compatible with many brands of DNA and RNA library preparation kits and library preparation processes are reported in the literature. They are used in the same way as the widely-adopted AMPure XP Beads. The library yield and size distribution achieved with the beads are highly consistent with those of AMPure XP Beads. Thus, the beads constitute a perfect replacement for AMPure XP Beads, effectively reducing the library preparation cost.