Interleukin 4 (IL-4) is a pleiotropic cytokine and plays a central role in humoral and adaptive immune responses. IL-4 is predominantly secreted by activated CD4+ memory and effector TH2 cells, basophils, and mast cells. It promotes the proliferation and differentiation of B cells, as well as immunoglobulin isotype switching, and MHC class II antigen and low-affinity IgE receptor expression. Furthermore, IL-4 induces the differentiation of naive CD4+ T cells into helper TH2 cells, while suppressing TH1 development, and promotes chemotaxis of mast cells and basophils. Excessive IL-4 production and mechanisms involving TH2 types have been associated with immunological disorders, such as IgE-mediated allergy.
Interleukin 4 (IL-4) is a pleiotropic cytokine and plays a central role in humoral and adaptive immune responses. IL-4 is predominantly secreted by activated CD4+ memory and effector TH2 cells, basophils, and mast cells. It promotes the proliferation and differentiation of B cells, as well as immunoglobulin isotype switching, and MHC class II antigen and low-affinity IgE receptor expression. Furthermore, IL-4 induces the differentiation of naive CD4+ T cells into helper TH2 cells, while suppressing TH1 development, and promotes chemotaxis of mast cells and basophils. Excessive IL-4 production and mechanisms involving TH2 types have been associated with immunological disorders, such as IgE-mediated allergy.
Interleukin 4 (IL-4) is a pleiotropic cytokine and plays a central role in humoral and adaptive immune responses. IL-4 is predominantly secreted by activated CD4+ memory and effector TH2 cells, basophils, and mast cells. It promotes the proliferation and differentiation of B cells, as well as immunoglobulin isotype switching, and MHC class II antigen and low-affinity IgE receptor expression. Furthermore, IL-4 induces the differentiation of naive CD4+ T cells into helper TH2 cells, while suppressing TH1 development, and promotes chemotaxis of mast cells and basophils. Excessive IL-4 production and mechanisms involving TH2 types have been associated with immunological disorders, such as IgE-mediated allergy.
Interleukin 4 (IL-4) is a pleiotropic cytokine and plays a central role in humoral and adaptive immune responses. IL-4 is predominantly secreted by activated CD4+ memory and effector TH2 cells, basophils, and mast cells. It promotes the proliferation and differentiation of B cells, as well as immunoglobulin isotype switching, and MHC class II antigen and low-affinity IgE receptor expression. Furthermore, IL-4 induces the differentiation of naive CD4+ T cells into helper TH2 cells, while suppressing TH1 development, and promotes chemotaxis of mast cells and basophils. Excessive IL-4 production and mechanisms involving TH2 types have been associated with immunological disorders, such as IgE-mediated allergy.