Pharmacokinetics by Institute of Molecular and Cell Biology (IMCB)

Pharmacokinetics studies are essential to any pharmaceutical researcher’s work

From in vivo to in vitro ADME studies, the effectiveness of your drugs can be tested with ease using our rodent (rat and mice) models.

Key Services

In vitro ADME studies

Permeability: PAMPA assay
Metabolic stability: Human, Rat, Mouse Liver Microsomes (HLM, RLM, MLM)
CYP inhibition studies

In vivo studies

Administration via IV, PO, IP, IM, SC routes
Rat carotid, jugular vein, bile duct cannulation
Determination of PK parameters (Tmax, Cmax, AUC 0-infinity)
Determination of oral bioavailability, clearance, volume of distribution
Tissue distribution studies
PK/PD studies in normal and diseased animals

Analysis

Small molecule bioanalysis