Technology Platforms

Allostery Platform by Bioinformatics Institute (BII)

TOWARDS DESING OF ALLOSTERIC PROTEINS/ DRUGS AND EXPLORING ALLOSTERIC EFFECT OF MUTATIONS

Allostery Platform by Bioinformatics Institute (BII) focuses on computational analysis of protein allostery which includes

Search/prediction of latent/new allosteric sites
Design of allosteric regulation in proteins of interest
Allosteric drug development
Allosteric effects of mutations

Figure 1: Protein function through the looking glass of allostery

Figure 2: SBSMMA outputs energetics of allosteric signalling

Key Techniques

State-of-the-art structure-based statistical mechanical model of allostery (SBSMMA)

Computational pipelines for gaining comprehensive allosteric control over protein activity, finding latent allosteric sites and design of allosteric drugs, and exploring the allosteric effects of SNPs.

Key Techniques

Allosteric drug design

Engineering of allosteric proteins

Analysis of drivers-passenger mutations in cancer landscapes

Allosteric effects of SNP

Figure 3: Comprehensive allosteric control of protein activity

Figure 4: Web-based and in-house resources

Key Techniques

BII-based in-house computational pipelines

Public web-server AlloSIgMA and web-database AlloMAPS for user’s preliminary analysis