High Throughput Screening (HTS) by EARO@EDDC

Screen up to 16,000 Compounds per Day per Project

The High Throughput Screening (HTS) platform specializes in small-molecule drug discovery projects and can help you to identify hits or tool compounds for your target/cell of interest. Several compound libraries are available (from small focus sets to large diverse collection of more than 300,000 curated compounds) to better cater your needs. Boasting a state-of-the-art and the only fully integrated automation platform in Singapore, the HTS platform can screen up to 16,000 compounds per day per project.

Scope of Services

• Drug Screening

• Target & Hit Identification

• Assay Development, Optimisation & Miniaturisation
  • A very broad range of target-class assays

Key Assay Expertise

• Fluorescence Polarisation

• nanoBRET

• nonaGLO HighBIT

• Fluorescence Assays (eg. FRET)

• Luminescence Assays (eg. Luciferase)

• Biophysical Assays

Sample Types

• Proteins/Enzymes

• Cultured Mammalian Cells

Key Technologies

• Azenta SampleStore II Compound Storage & Management Systems
  

• Beckman Complete Automation Integrated Deck
  • Cell Seeding
  • Compound Treatment
  • Reagent Dispensing
  • Plate Washing
  • Assay Readouts

• Agilent DDR Integrated Liquid Handling Deck

• Microplate Washers & Dispensers
  • Agilent-BioTek 405TS Washer with Stacker
  • Thermo Multidrop Combi Bulk Dispenser
    

• High Throughput Plate Readers
  • Tecan Spark Multimode Reader
  • Tecan Infinite M1000 Pro