Fragment Based Screening (FBS) is a validated approach towards finding high quality hits against challenging proteins that are classified as undruggable. A team of experts at the FBS employ proprietary library and a cascade of biophysical techniques, to find ligand efficient fragment hits against targets in the oncology and infectious disease space.
The fragment library @ FBS covers a wide range of chemical spaces and is suitable for diverse targets such as DNA Gyrase and undruggable targets such as protein-protein interactions. The screening methods are able to identify fragments binding weakly to the target (affinity in mM range). EDDC has diverse methodologies to monitor fragment growth, which can be achieved through measuring binding affinities, activities or competition assays.
In summary, FBS offers expertise for projects involving fragment identification using binding and competition assays, characterization of protein-fragment interactions, map the ligand binding site, designing fragment growth and target-lead interactions.