Protein Structure & Biophysics (PSB) by EARO@EDDC

The Protein Structure & Biophysics (PSB) platform specializes in the determination of high-resolution structures of proteins and protein-ligand complexes. In the context of drug development, understanding protein-ligand interactions is pivotal for accelerating lead identification structure-guidedided lead optimisation.

The PSB team provides solutions tailored to your needs starting from construct design, protein expression & purification, screening for crystal hit identification & optimisation of crystallisation conditions to atomic structure solution. The PSB team has access to both in-house diffractometers and commercial beamline at synchrotrons to provide fast turnaround to your projects. Experienced crystallographers with expertise on various target proteins will work together with the clients.

Scope of Services

Construct Design for Protein of Interest

Protein Expression and Purification

High Throughout Crystallisation Screens

Crystal Optimisation for Proteins and Protein Complexes

Structure Solution and Analysis

Epitope Mapping for Antigen-Antibody Interactions

High Throughput Fragment Screening (FBDD)

Key Techniques/Expertise

Protein Purification

Protein Structure Determination (X-ray Crystallography)

Structure Analysis

ThermoFluor

Epitope Mapping

Key Instruments/Technologies

Commercial synchrotron beamtime access for protein crystals and SAXS

ÄKTAxpress

LEX Incubator

To learn more about EARO, please visit www.earo.sg.

The PSB Platform is part of the EARO initiative, whose mission is to accelerate early-stage drug discovery in Singapore by providing access to EDDC’s expertise in Drug Discovery & Development and its industry-leading technologies.