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Protein Structure & Biophysics by Experimental Drug Development Centre (EDDC)

Understanding protein-ligand interactions is pivotal for accelerating lead identification and structure guided lead optimisation. Our structural biology & biophysical screening platform supports target-based drug discovery projects at EDDC. Protein crystallography is used to determine high-resolution structures of proteins and ligand binding conformations. Using a proprietary library and a cascade of biophysical techniques, EDDC’s Fragment Based Screening platform is consistently able to find ligand efficient fragment hits against targets in the oncology and infectious disease space.

1. Protein Crystallography 

Understanding protein-ligand interactions is pivotal for accelerating lead identification and structure guided lead optimisation. Our team of experts at the X-ray crystallography (XRAY) platform support the determination of high-resolution structures of proteins and ligand binding conformations...Find out more

2. Fragment Based Screening

Fragment Based Screening (FBS) is a validated approach towards finding high quality hits against challenging proteins that are classified as undruggable. A team of experts at the FBS employ proprietary library and a cascade of biophysical techniques, to find ligand efficient fragment hits against targets in the oncology and infectious disease space...Find out more

 

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Protein Structure & Biophysics consisting of Fragment Based Screening (FBS) and Protein crystallography (XRAY) is part of the EDDC Academic Research Organisation or EARO, a Fee-for-Service initiative by the Experimental Drug Development Centre (EDDC). Founded in 2020, EARO was conceived to provide greater access to EDDC’s rich scientific expertise and state of the art technology platforms to the academic and industry researchers in the biomedical ecosystem who aspire to embark on a journey of translating their research into drug candidates. EARO comprises primarily of 5 core drug discovery platforms headed by scientists with decades of experience.  The EARO Platforms include High Throughput Screening (HTS), Fragment Based Screening (FBS), Protein Crystallography (XRAY), High Throughput Phenomics (HTP) and Computational Phenomics Platforms (CPP). Together, EARO groups have engaged with more than 70 academic and industry partners.
 
Visit https://www.earo.sg/ for more information  or email enquiries@rsc.a-star.edu.sg
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