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Protein Structure & Biophysics (PSB) by EARO@EDDC

The Protein Structure & Biophysics (PSB) platform specializes in the determination of high-resolution structures of proteins and protein-ligand complexes. In the context of drug development, understanding protein-ligand interactions is pivotal for accelerating lead identification structure-guidedided lead optimisation.


The PSB team provides solutions tailored to your needs starting from construct design, protein expression & purification, screening for crystal hit identification & optimisation of crystallisation conditions to atomic structure solution. The PSB team has access to both in-house diffractometers and commercial beamline at synchrotrons to provide fast turnaround to your projects. Experienced crystallographers with expertise on various target proteins will work together with the clients.



Scope of Services

  • Construct Design for Protein of Interest  
  • Protein Expression and Purification
  • High Throughout Crystallisation Screens
  • Crystal Optimisation for Proteins and Protein Complexes
  • Structure Solution and Analysis
  • Epitope Mapping for Antigen-Antibody Interactions
  • High Throughput Fragment Screening (FBDD) 


Key Techniques/Expertise

  • Protein Purification
  • Protein Structure Determination (X-ray Crystallography)
  • Structure Analysis
  • ThermoFluor
  • Epitope Mapping


PSB Structures Composite

Key Instruments/Technologies

  • Commercial synchrotron beamtime access for protein crystals and SAXS
  • ÄKTAxpress
  • LEX Incubator


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To learn more about EARO, please visit

The PSB Platform is part of the EARO initiative, whose mission is to accelerate early-stage drug discovery in Singapore by providing access to EDDC’s expertise in Drug Discovery & Development and its industry-leading technologies.